A Grignard reagent is an organomagnesium compound which can be described by the chemical formula ‘R-Mg-X’ where R refers to an alkyl or aryl group and X refers to a halogen.
They are generally produced by reacting an aryl halide or an alkyl halide with magnesium.
Grignard reagents (RMgX) are commonly used for organic synthesis. However, these highly reactive compounds are supplied inflammable solvents, which cause extra complexity in their transport. Herein we note that Grignard reagents with linear alkyl chains can be trapped and stabilized by the macrocyclic host pillar arene while retaining their reactivity.
The Grignard reaction is an organic reaction used to produce a variety of products through the reaction of an organomagnesium compound, also known as an electrophilic “Grignard reagent,” followed by an acidic reaction. The Grignard reagent is formed by the reaction of an alkyl or aryl halide with magnesium metal via a radical mechanism.
The process of preparing Grignard reagents is described in the points provided below. It can be noted that many of these reagents can also be purchased commercially.